Thomas Eckhard Hundhausen

• Wilson, Siobhan M.; Bohn, Mary Kathryn; Madsen, Andre Greger; Hundhausen, Thomas Eckhard & Adeli, Khosrow (2023). LMS-based continuous reference percentiles for 14 laboratory parameters in the CALIPER cohort of healthy children and adolescents. Clinical Chemistry and Laboratory Medicine. ISSN 1434-6621. 61(6). doi: 10.1515/cclm-2022-1077. Vis sammendrag

  Objectives Marked physiological changes in growth and development present challenges in defining pediatric reference intervals for biomarkers of health and disease. Lambda, Mu, and Sigma (LMS)-based statistical modeling provides a continuous normal distribution by negating skewness and variation, and is commonly used to establish growth charts. Such LMS reference curves are suggested to enhance laboratory test result interpretation. The current study establishes LMS-based continuous reference percentiles for 14 biomarkers in the CALIPER cohort of healthy children and adolescents. Methods Data from healthy children and adolescents aged 1–<19 years were used to establish continuous reference percentiles using a novel LMS-based statistical method, including 2.5th, 25th, 50th, 75th, and 97.5th percentiles. The LMS approach applies a Box-Cox data transformation and summarizes continuous distributions by age via three curves: skewness (Lambda), median (Mu), and coefficient of variation (Sigma). Results LMS-based percentiles and z-scores were generated for 14 common pediatric biomarkers that demonstrate dynamic concentration patterns with age (e.g., alkaline phosphatase) and/or wherein the magnitude of difference from the population mean may be clinically relevant (e.g., triglycerides). The LMS model captured age- and sex-specific distributions accurately and was not substantially influenced by outlying points. Conclusions This is the first study to establish LMS-based continuous reference percentiles for biochemical markers in a healthy Canadian pediatric population. The current LMS-based approach builds upon previous continuous reference interval models by providing graded percentiles to improve test result interpretation, particularly with repeated measures over time. This method may assist in facilitating a patient-centered approach to laboratory medicine.

• Madsen, Andre; Almås, Bjørg; Bruserud, Ingvild Særvold; Oehme, Ninnie Helen Bakken; Nielsen, Christopher Sivert & Roelants, Mathieu [Vis alle 13 forfattere av denne artikkelen] (2022). Reference Curves for Pediatric Endocrinology: Leveraging Biomarker Z-Scores for Clinical Classifications. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 107(7), s. 2004–2015. doi: 10.1210/clinem/dgac155. Fulltekst i vitenarkiv Vis sammendrag

  Context Hormone reference intervals in pediatric endocrinology are traditionally partitioned by age and lack the framework for benchmarking individual blood test results as normalized z-scores and plotting sequential measurements onto a chart. Reference curve modeling is applicable to endocrine variables and represents a standardized method to account for variation with gender and age. Objective We aimed to establish gender-specific biomarker reference curves for clinical use and benchmark associations between hormones, pubertal phenotype, and body mass index (BMI). Methods Using cross-sectional population sample data from 2139 healthy Norwegian children and adolescents, we analyzed the pubertal status, ultrasound measures of glandular breast tissue (girls) and testicular volume (boys), BMI, and laboratory measurements of 17 clinical biomarkers modeled using the established “LMS” growth chart algorithm in R. Results Reference curves for puberty hormones and pertinent biomarkers were modeled to adjust for age and gender. Z-score equivalents of biomarker levels and anthropometric measurements were compiled in a comprehensive beta coefficient matrix for each gender. Excerpted from this analysis and independently of age, BMI was positively associated with female glandular breast volume (β = 0.5, P < 0.001) and leptin (β = 0.6, P < 0.001), and inversely correlated with serum levels of sex hormone-binding globulin (SHBG) (β = −0.4, P < 0.001). Biomarker z-score profiles differed significantly between cohort subgroups stratified by puberty phenotype and BMI weight class. Conclusion Biomarker reference curves and corresponding z-scores provide an intuitive framework for clinical implementation in pediatric endocrinology and facilitate the application of machine learning classification and covariate precision medicine for pediatric patients.

• Hope, Sigrun; Nærland, Terje; Høyland, Anne Lise; Torske, Tonje; Malt, Eva & Abrahamsen, Tore G [Vis alle 16 forfattere av denne artikkelen] (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years. The FASEB Journal. ISSN 0892-6638. 34(6), s. 8114–8124. doi: 10.1096/fj.201900855RRR. Fulltekst i vitenarkiv
• Hundhausen, Thomas Eckhard; Lacsamana, Nancy; Tednes, Uraiwan & Slettan, Audun (2014). RHD-genotyping ved bruk av allel-spesifikk "Loop-mediated isothermal DNA Amplification". Bioingeniøren. ISSN 0801-6828. 49(3), s. 16–21.

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• Hundhausen, Thomas Eckhard & Milan, Elena Margarita (2015). Hæmatologi for 8. trinn-elever, ungdomsskole.
• Hundhausen, Thomas Eckhard (2015). Vitamin B12 i Vest-Agder - Referanseintervaller.
• Hundhausen, Thomas Eckhard (2013). Protrahert væskedeficit hos trombocytt-aferese-givere.
• Hundhausen, Thomas Eckhard; Mathiassen, M.; Børresen, H.U.; Nedal, K.A. & Olsen, Odd Harald (2013). PROLONGED INTRAVASAL FLUID DEFICITS IN PLATELETPHERESIS DONORS. Vox Sanguinis. ISSN 0042-9007. 105, s. 49–49.
• Hundhausen, Thomas Eckhard (2012). Infeksjoner som kan overføres ved transfusjon.
• Hundhausen, Thomas Eckhard & Milan, Elena Margarita (2012). Hæmatologi for 8. trinn-elever, ungdomsskole.
• Hundhausen, Thomas Eckhard (2011). Hæmatologi for 8. trinn-elever, ungdomsskole.

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