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I1043 ( Universitetsveien 25, Kristiansand )

My current research follows two main themes: (a) studying mitochondrial viability and targeted nutritional interventions to tackle impaired bioenergetics in health and disease, and (b) analyzing population health metrics in chronic cardiometabolic diseases. My research expertise and experience include pre-clinical and clinical development of mitochondria-related nutraceuticals, randomized controlled trials with nutritional interventions, pharmacokinetics of dietary supplements, tissue-specific metabolic assessment and translation, and clinical physiology.

ResearhGate | ORCID ID | PubMed

Research interests

Nutritional neuroscience

Bioenergetics / Energy Metabolism


Randomized controlled trials


Molecular nutrition


Courses and teaching

ERN 205

ERN 211


Sergej Ostojic is a member of international research networks in population health, including European Childhood Obesity Surveillance Initiative (World Health Organization), NCD Risk Factor Collaboration (Imperial College London), and Global Burden of Disease (University of Washington).

List of of recent scientific projects registered at ClinicalTrials.gov is availlable here

Selected publications

Top 10 papers in 2021

Ostojic SM. Guanidinoacetic acid loading for improved location-specific brain creatine. Clinical Nutrition, 2021;40(1):324-326. DOI: 10.1016/j.clnu.2020.05.003.

Ostojic SM, Forbes SC. Creatine, a conditionally essential nutrient: building the case. Advances in Nutrition, 2021. DOI: 10.1093/advances/nmab111.

Ostojic SM. Hydrogen-rich water as a modulator of gut microbiota? Journal of Functional Foods, 2021;78:104360. DOI: 10.1016/j.jff.2021.104360.

Ostojic SM. Hydrogen as a potential therapeutics in obesity: targeting the brain. Trends in Endocrinology and Metabolism, 2021;32(4):191-193. DOI: 10.1016/j.tem.2021.01.002.

Korovljev D, Stajer V, Ostojic SM. Relationship between dietary creatine and growth indicators in children and adolescents aged 2–19 years: a cross-sectional study. Nutrients. 2021;13(3):1027. DOI: 10.3390/nu13031027.

Ostojic SM. Stimulation of CT1 function: from Klotho protein to ammonia and beyond. Frontiers in Nutrition, 2021;8:660021. DOI: 10.3389/fnut.2021.660021.

Ostojic SM. Creatine as a food supplement for the general population. Journal of Functional Foods, 2021. DOI: 10.1016/j.jff.2021.104568.

Korovljev D, Todorovic N, Stajer V, Ostojic SM. Temporal trends in dietary creatine intake from 1999 to 2018: an ecological study with 89,161 participants. Journal of the International Society of Sport Nutrition, 2021;18:53. DOI: 10.1186/s12970-021-00453-1.

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1,201 population-representative studies with 104 million participants. Lancet, 2021. DOI: 10.1016/S0140-6736(21)01330-1.

GBD 2019 Collaborators. Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019. Alzheimers Dement (N Y). 2021;7(1):e12200. DOI: 10.1002/trc2.12200.



General outreach

Sergej Ostojic is Associate Editor of the scientific journals Frontiers in Physiology and Research in Sports Medicine, Review Editor for Frontiers in Pharmacology, Frontiers in Nutrition and International Journal of Public Health, Editorial Consultant for Current Topics in Nutraceutical Research, and Editorial Board member for Food Science and Nutrition and Journal of Functional Foods.

He is also a member of the American College of Physicians, the American Society for Nutrition, the American Physiological Society, the Nutrition Society, International Society for Cerebral Blood Flow and Metabolism, and Mitochondrial Medicine Society.

Scientific publications

  • Ostojic, Sergej (2022). Cataloguing guanidinoacetic acid content in various foods. International Journal for Vitamin and Nutrition Research. ISSN: 0300-9831. doi:10.1024/0300-9831/a000753.
  • Forbes, Scott C; Cordingley, Dean; Cornish, Stephen; Gualano, Bruno; Roschel, Hamilton; Ostojic, Sergej; Rawson, Eric S; Roy, Brian; Prokopidis, Konstantinos; Giannos, Panagiotis; Candow, Darren G (2022). Effects of Creatine Supplementation on Brain Function and Health. Nutrients. ISSN: 2072-6643. 14 (5). doi:10.3390/nu14050921.
  • GBD 2019 AGEING COLLABORATORS, GBD 2019 AGEING COLLABORATORS; Ostojic, Sergej (2022). Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study. The BMJ. ISSN: 1756-1833. 376 (e068208). doi:10.1136/bmj-2021-068208.
  • Ostojic, Sergej; Ostojic, Jelena; Zanini, Dragana; Jezdimirovic, Tatjana; Stajer, Valdemar (2022). Guanidinoacetate–creatine in secondary progressive multiple sclerosis: a case report. Journal of International Medical Research. ISSN: 0300-0605. 50 (1). s 1 - 5. doi:10.1177/03000605211073305.
  • Milovancev, Aleksandra; Avakumovic, Jovana; Drid, Patrik; Todorovic, Nikola; Stajer, Valdemar; Ostojic, Sergej (2022). Hydrogen-rich water alleviates inflammation and fatigue in COVID-19: A pilot study. European Journal of Inflammation. ISSN: 2058-7392. 20doi:10.1177/1721727X221094197.
  • Ostojic, Sergej (2022). Low tissue creatine: a therapeutic target in clinical nutrition. Nutrients. ISSN: 2072-6643. 14 (6). doi:10.3390/nu14061230.
  • Korovljev, Darinka; Todorovic, Nikola; Stajer, Valdemar; Ostojic, Sergej (2021). Food Creatine and DXA-Derived Body Composition in Boys and Girls aged 8-19 Years. Nutrition and Metabolic Insights. ISSN: 1178-6388. 14s 1 - 5. doi:10.1177/11786388211059368.
  • Ostojic, Sergej (2022). Relationship between dietary creatine and growth indicators in children and adolescents aged 2-19 years.
  • Ostojic, Sergej (2022). Creatine and post-viral fatigue syndrome: an overview..

Last changed: 15.12.2021 10:12